Comparative genome analysis of 15 clinical Shigella flexneri strains regarding virulence and antibiotic resistance.

ABSTRACT: Shigellosis is the major cause of dysentery globally. It is mainly attributed to two Shigella species, Shigella sonnei and Shigella flexneri, which leads to approximately 165 million infections and 1.1 million deaths each year. Rapid increase and widening of spectrum in antibiotics resistance make Shigella hard to be adequately controlled through existing prevention and treatment measures. It has also been observed that enhanced virulence and advent of antibiotic resistance (AR) could arise almost simultaneously. However, genetic linkages between the two factors are missing or largely ignored, which hinders experimental verification of the relationship. In this study, we sequenced 15 clinically isolated S. flexneri strains. Genome assembly, annotation and

SUBMITTER: Wang L 

PROVIDER: S-EPMC6787350 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature