Gadolinium-Labelled Cell Scaffolds to Follow-up Cell Transplantation by Magnetic Resonance Imaging.

ABSTRACT: Cell scaffolds are often used in cell transplantation as they provide a solid structural support to implanted cells and can be bioengineered to mimic the native extracellular matrix. Gadolinium fluoride nanoparticles (Gd-NPs) as a contrast agent for Magnetic Resonance Imaging (MRI) were incorporated into poly(lactide-co-glycolide)/chitosan scaffolds to obtain Imaging Labelled Cell Scaffolds (ILCSs), having the shape of hollow spherical/ellipsoidal particles (200-600 μm diameter and 50-80 μm shell thickness). While Gd-NPs incorporated into microparticles do not provide any contrast enhancement in T₁-weighted (T₁w) MR images, ILCSs can release Gd-NPs in a controlled manner, thus activating MRI contrast. ILCSs seeded with human mesenchymal stromal cells (hMSCs) were xeno

SUBMITTER: Catanzaro V 

PROVIDER: S-EPMC6787680 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature