Long-term efficacy of interventions for actinic keratosis: protocol for a systematic review and network meta-analysis.

ABSTRACT:

Background

Actinic keratoses (AK) are common precancerous lesions of the skin due to cumulative sun exposure. A variety of interventions are available for the treatment; however, the majority of randomised controlled trials (RCTs) and meta-analyses focus on short-term efficacy outcomes. This network meta-analysis aims to investigate the long-term (> 12 months) efficacy of interventions for AK.

Methods

To identify relevant studies, we will perform a systematic literature research in MEDLINE, Embase, and CENTRAL and hand-search pertinent trial registers. Two authors will independently screen titles and abstracts for eligibility. We will include RCTs with an inter-individual (parallel arm) design. The study population includes patients with a clinical or histopathologic diagnos

SUBMITTER: Steeb T 

PROVIDER: S-EPMC6788027 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature