N-Doped Graphene Oxide Decorated with PtCo Nanoparticles for Immobilization of Double-Stranded Deoxyribonucleic Acid and Investigation of Clenbuterol-Induced DNA Damage.

ABSTRACT: We demonstrate here a facile hydrothermal-assisted formation of PtCo alloy nanoparticles (NPs) and their simultaneous anchoring on the graphitic surface of N-doped graphene oxide (NGO). Doping induced nanopores in the carbon surface to facilitate the uniform and homogeneous anchoring of alloy nanoparticles. It was revealed that the formation of PtCo NPs on an NGO interface plodded excellent tendency toward double-stranded deoxyribonucleic acid (dsDNA). The dsDNA immobilization was enabled by the presence of several oxidation states of Pt and Co. The same property was further used to monitor the direct detection of dsDNA damage induced by clenbuterol via screen-printed carbon electrodes. Cyclic voltammetric and electrochemical impedance spectroscopic characterization traced well the dsDNA a

SUBMITTER: Nawaz MH 

PROVIDER: S-EPMC6788047 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature