Exploiting xylan as sugar donor for the synthesis of an antiproliferative xyloside using an enzyme cascade.

ABSTRACT:

Background

Currently, industrial societies are seeking for green alternatives to conventional chemical synthesis. This demand has merged with the efforts to convert lignocellulosic biomass into value-added products. In this context, xylan, as one of main components of lignocellulose, has emerged as a raw material with high potential for advancing towards a sustainable economy.

Results

In this study, the recombinant endoxylanase rXynM from the ascomycete Talaromyces amestolkiae has been heterologously expressed in Pichia pastoris and used as one of the catalysts of an enzyme cascade developed to synthesize the antiproliferative 2-(6-hydroxynaphthyl) β-D-xylopyranoside, by transglycosylation of 2,6-dihydroxynaphthalene. The approach combines the use of two fungal xylanolytic e

SUBMITTER: Nieto-Dominguez M 

PROVIDER: S-EPMC6788083 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature