The therapeutic effects of microRNAs in preclinical studies of acute kidney injury: a systematic review protocol.

ABSTRACT:

Background

Acute kidney injury (AKI) causes significant morbidity and mortality in humans, and there are currently no effective treatments to enhance renal recovery. MicroRNAs (miRNAs) are short chain nucleotides that regulate protein expression and have been implicated in the pathogenesis of AKI. Recently, preclinical studies in vivo have uncovered a therapeutic role for administration of specific miRNAs in AKI. However, the overall benefits of this strategy in preclinical studies have not been systematically reviewed, and the potential for translation to human studies is unclear.

Aim

The primary aim is to conduct a systematic review of the therapeutic properties of miRNAs in preclinical studies of AKI. The secondary aim is to determine potential adverse effects of miRNA ad

SUBMITTER: Zankar S 

PROVIDER: S-EPMC6788089 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature