Nanostructured lipid carriers of ivermectin as a novel drug delivery system in hydatidosis.

ABSTRACT:

Background

The larval stage of the tapeworm Echinococcus granulosus is the causative agent of hydatid disease in humans. This zoonotic parasitic infection remains a major health problem in certain areas of the world where is still endemic. In view of the ineffectiveness of some drug treatments, the surgical removal of cysts remains the preferred treatment option together with the administration of albendazole and mebendazole. However, severe side effects of these drugs have been reported which demands developing new scolicidal agents that confer suitable efficacy and fewer side effects during surgery.

Methods

To that purpose, in the present work we assessed the effectiveness of ivermectin (IVM), a macrocyclic lactone endectocide that has shown to be an effective nematocidal

SUBMITTER: Ahmadpour E 

PROVIDER: S-EPMC6788095 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature