From cortex to cord: motor circuit plasticity after spinal cord injury.

ABSTRACT: Spinal cord injury is associated with chronic sensorimotor deficits due to the interruption of ascending and descending tracts between the brain and spinal cord. Functional recovery after anatomically complete spinal cord injury is limited due to the lack of long-distance axonal regeneration of severed fibers in the adult central nervous system. Most spinal cord injuries in humans, however, are anatomically incomplete. Although restorative treatment options for spinal cord injury remain currently limited, research from experimental models of spinal cord injury have revealed a tremendous capability for both spontaneous and treatment-induced plasticity of the corticospinal system that supports functional recovery. We review recent advances in the understanding of corticospinal circuit plasti

SUBMITTER: Brown AR 

PROVIDER: S-EPMC6788232 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature