The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases.

ABSTRACT: The neuro-glial interface extends far beyond mechanical support alone and includes interactions throu-gh coagulation cascade proteins. Here, we systematically review the evidence indicating that synaptic and node of Ranvier glia cell components modulate synaptic transmission and axonal conduction by a coagulation cascade protein system, leading us to propose the concept of the neuro-glial coagulonome. In the peripheral nervous system, the main thrombin receptor protease activated receptor 1 (PAR1) is located on the Schwann microvilli at the node of Ranvier and at the neuromuscular junction. PAR1 activation effects can be both neuroprotective or harmful, depending on thrombin activity levels. Low physiological levels of thrombin induce neuroprotective effects in the Schwann cells which are

SUBMITTER: Gofrit SG 

PROVIDER: S-EPMC6788244 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature