Differential gene and protein expression between rat tibial nerve and common peroneal nerve during Wallerian degeneration.

ABSTRACT: Wallerian degeneration and nerve regeneration after injury are complex processes involving many genes, proteins and cytokines. After different peripheral nerve injuries the regeneration rate can differ. Whether this is caused by differential expression of genes and proteins during Wallerian degeneration remains unclear. The right tibial nerve and the common peroneal nerve of the same rat were exposed and completely cut through and then sutured in the same horizontal plane. On days 1, 7, 14, and 21 after surgery, 1-2 cm of nerve tissue distal to the suture site was dissected out from the tibial and common peroneal nerves. The differences in gene and protein expression during Wallerian degeneration of the injured nerves were then studied by RNA sequencing and proteomic techniques. In the tib

SUBMITTER: Lin YF 

PROVIDER: S-EPMC6788246 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature