Limited applicability of cathepsin D for the diagnosis and monitoring of non-alcoholic steatohepatitis.

ABSTRACT:

Background and aim

To date, there are limited data on the applicability of cathepsin D for the diagnosis and monitoring of non-alcoholic steatohepatitis (NASH).

Methods

This study included patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) diagnosed between November 2012 and October 2015. Serum cathepsin D levels were measured using the CatD enzyme-linked immunosorbent assay (USCN Life Science, Wuhan, China) using stored samples collected on the same day of the liver biopsy procedure. The performance of cathepsin D in the diagnosis and monitoring of NASH was evaluated using receiver operating characteristic analysis.

Results

Data for 216 liver biopsies and 34 healthy controls were analyzed. The mean cathepsin D level was not significantly different

SUBMITTER: Kamarajah SK 

PROVIDER: S-EPMC6788371 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature