Ectonucleotidases in Blood Malignancies: A Tale of Surface Markers and Therapeutic Targets.

ABSTRACT: Leukemia develops as the result of intrinsic features of the transformed cell, such as gene mutations and derived oncogenic signaling, and extrinsic factors, such as a tumor-friendly, immunosuppressed microenvironment, predominantly in the lymph nodes and the bone marrow. There, high extracellular levels of nucleotides, mainly NAD⁺ and ATP, are catabolized by different ectonucleotidases, which can be divided in two families according to substrate specificity: on one side those that metabolize NAD⁺, including CD38, CD157, and CD203a; on the other, those that convert ATP, namely CD39 (and other ENTPDases) and CD73. They generate products that modulate intracellular calcium levels and that activate purinergic receptors. They can also converge on adenosine generation with

SUBMITTER: Vaisitti T 

PROVIDER: S-EPMC6788384 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature