Implications of renin-angiotensin-system blocker discontinuation in acute decompensated heart failure with systolic dysfunction.

ABSTRACT:

Background

Renin-angiotensin-system blockers (RASB) improve clinical outcomes in patients with chronic heart failure with reduced fraction; however, there remains ambiguity whether RASB therapy should be continued during the treatment of acute decompensated heart failure (ADHF).

Hypothesis

In comparison to patients with RASB use, RASB discontinuation in ADHF will be associated with worsening renal function, hypotension, and adverse long-term clinical outcomes.

Methods

Patients in the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization (ESCAPE) trial were separated into four groups based on RASB use at baseline and discharge: continuation (n = 316), discontinuation (n = 21), initiation (n = 42), and nonuse (n = 23). Post-discharge outcomes

SUBMITTER: Darden D 

PROVIDER: S-EPMC6788475 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature