Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum.

ABSTRACT: The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit that is composed of defined cell types, which approximately account for more than half of neurons in mammals. The molecular mechanisms controlling developmental progression and maturation processes of various cerebellar cell types need systematic investigation. Here, we analyzed transcriptome profiles of 21119 single cells of the postnatal mouse cerebellum and identified eight main cell clusters. Functional annotation of differentially expressed genes revealed trajectory hierarchies of granule cells (GCs) at various states and implied roles of mitochondrion and ATPases in the maturation of Purkinje cells (PCs), the sole output cells of the cerebellar cortex. Furthermore, we analyzed gene express

SUBMITTER: Peng J 

PROVIDER: S-EPMC6788728 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature