Extensive global movement of multidrug-resistantM. tuberculosis strains revealed by whole-genome analysis.

ABSTRACT:

Background

While the international spread of multidrug-resistant (MDR) Mycobacterium tuberculosis strains is an acknowledged public health threat, a broad and more comprehensive examination of the global spread of MDR-tuberculosis (TB) using whole-genome sequencing has not yet been performed.

Methods

In a global dataset of 5310 M. tuberculosis whole-genome sequences isolated from five continents, we performed a phylogenetic analysis to identify and characterise clades of MDR-TB with respect to geographic dispersion.

Results

Extensive international dissemination of MDR-TB was observed, with identification of 32 migrant MDR-TB clades with descendants isolated in 17 unique countries. Relatively recent movement of strains from both Beijing and non-Bei

SUBMITTER: Cohen KA 

PROVIDER: S-EPMC6788793 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature