Cutaneous TRPV1⁺ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity.

ABSTRACT: Cutaneous TRPV1⁺ neurons directly sense noxious stimuli, inflammatory cytokines, and pathogen-associated molecules and are required for innate immunity against some skin pathogens. Important unanswered questions are whether TRPV1⁺ neuron activation in isolation is sufficient to initiate innate immune responses and what is the biological function for TRPV1⁺ neuron-initiated immune responses. We used TRPV1-Ai32 optogenetic mice and cutaneous light stimulation to activate cutaneous neurons in the absence of tissue damage or pathogen-associated products. We found that TRPV1⁺ neuron activation was sufficient to elicit a local type 17 immune response that augmented host defense to C. albicans and S. aureus. Moreover, local neuron activation elicited ty

SUBMITTER: Cohen JA 

PROVIDER: S-EPMC6788801 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature