Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.

ABSTRACT:

Background & aims

Spontaneous clearance of hepatitis C virus (HCV) occurs in approximately 30% of infected persons and less often in populations of African ancestry. Variants in major histocompatibility complex (MHC) and in interferon lambda genes are associated with spontaneous HCV clearance, but there have been few studies of these variants in persons of African ancestry. We performed a dense multi-ancestry genome-wide association study of spontaneous clearance of HCV, focusing on individuals of African ancestry.

Methods

We performed genotype analyses of 4423 people from 3 ancestry groups: 2201 persons of African ancestry (445 with HCV clearance and 1756 with HCV persistence), 1739 persons of European ancestry (701 with HCV clearance and 1036 with HCV persistence), and 486

SUBMITTER: Vergara C 

PROVIDER: S-EPMC6788806 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature