Positioning a multifunctional basic helix-loop-helix transcription factor within the Ciona notochord gene regulatory network.

ABSTRACT: In a multitude of organisms, transcription factors of the basic helix-loop-helix (bHLH) family control the expression of genes required for organ development and tissue differentiation. The functions of different bHLH transcription factors in the specification of nervous system and paraxial mesoderm have been widely investigated in various model systems. Conversely, the knowledge of the role of these regulators in the development of the axial mesoderm, the embryonic territory that gives rise to the notochord, and the identities of their target genes, remain still fragmentary. Here we investigated the transcriptional regulation and target genes of Bhlh-tun1, a bHLH transcription factor expressed in the developing Ciona notochord as well as in additional embryonic territories that contribute

SUBMITTER: Kugler JE 

PROVIDER: S-EPMC6788811 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature