Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell.

ABSTRACT:

Objectives

Rheumatoid arthritis (RA) is an autoimmune disease accompanied by lymphocyte infiltration into joint synovium. While T cells are considered to be important for its pathogenesis, the features that are the most relevant to disease and how they change after treatment remain unclear. The aim of this study was to clarify the characteristics of T cells in RA, comprehensively.

Methods

We enrolled a total of 311 patients with RA and 73 healthy participants, and carefully classified them by disease state, constructed multiple cohorts and analysed clinical samples from them in a stepwise manner. We performed immunophenotyping with multiple evaluation axes, and two independent transcriptome analyses complementary to each other.

Results

We identified that 'effector mem

SUBMITTER: Takeshita M 

PROVIDER: S-EPMC6788883 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature