Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis.

ABSTRACT: Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection, microbiota composition and metabolism¹. ILC3s and neuronal cells have been shown to interact at discrete mucosal locations to steer mucosal defence^2,3. Nevertheless, it is unclear whether neuroimmune circuits operate at an organismal level, integrating extrinsic environmental signals to orchestrate ILC3 responses. Here we show that light-entrained and brain-tuned circadian circuits regulate enteric ILC3s, intestinal homeostasis, gut defence and host lipid metabolism in mice. We found that enteric ILC3s display circadian expression of clock genes and ILC3-related transcription factors. ILC3-autonomous ablation of the circadian regulator Arntl led to disrupted gut ILC3 homeostasis, im

SUBMITTER: Godinho-Silva C 

PROVIDER: S-EPMC6788927 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature