Associations between single nucleotide polymorphisms in miR-221, self-reported essential hypertension, and interactions between genetic and environmental factors: a multiethnic study in China.

ABSTRACT: This case-control study explored the relationship between SNPs in miR-221 and self-reported essential hypertension, as well as interactions between genetic and environmental factors, in a multiethnic Chinese cohort. A MassArray analysis was performed to genotype 462 patients with essential hypertension and 442 healthy participants. The association between four SNPs in miR-221 and essential hypertension risk was determined by investigating the differences in allelic and genotypic frequencies between case and control groups using PLINK version 1.07 software. A 4 × 2 table approach was conducted to explore the synergistic effect of SNPs and environmental factors on the risk of essential hypertension. Subjects with the C allele of rs2858060 in miR-221 had a lower risk of essential hypertension

SUBMITTER: An F 

PROVIDER: S-EPMC6789256 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature