Optimal compressed sensing strategies for an array of nonlinear olfactory receptor neurons with and without spontaneous activity.

ABSTRACT: There are numerous different odorant molecules in nature but only a relatively small number of olfactory receptor neurons (ORNs) in brains. This "compressed sensing" challenge is compounded by the constraint that ORNs are nonlinear sensors with a finite dynamic range. Here, we investigate possible optimal olfactory coding strategies by maximizing mutual information between odor mixtures and ORNs' responses with respect to the bipartite odor-receptor interaction network (ORIN) characterized by sensitivities between all odorant-ORN pairs. For ORNs without spontaneous (basal) activity, we find that the optimal ORIN is sparse-a finite fraction of sensitives are zero, and the nonzero sensitivities follow a broad distribution that depends on the odor statistics. We show analytically that sparsit

SUBMITTER: Qin S 

PROVIDER: S-EPMC6789560 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature