SerpinB1 controls encephalitogenic T helper cells in neuroinflammation.

ABSTRACT: SerpinB1, a protease inhibitor and neutrophil survival factor, was recently linked with IL-17-expressing T cells. Here, we show that serpinB1 (Sb1) is dramatically induced in a subset of effector CD4 cells in experimental autoimmune encephalomyelitis (EAE). Despite normal T cell priming, Sb1^-/- mice are resistant to EAE with a paucity of T helper (T_H) cells that produce two or more of the cytokines, IFNγ, GM-CSF, and IL-17. These multiple cytokine-producing CD4 cells proliferate extremely rapidly; highly express the cytolytic granule proteins perforin-A, granzyme C (GzmC), and GzmA and surface receptors IL-23R, IL-7Rα, and IL-1R1; and can be identified by the surface marker CXCR6. In Sb1^-/- mice, CXCR6⁺ T_H c

SUBMITTER: Hou L 

PROVIDER: S-EPMC6789640 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature