Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications.

ABSTRACT: Prostate cancer is the most frequent nonskin cancer and second most common cause of cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with many patients exhibiting an aggressive disease with progression, metastasis, and other patients showing an indolent disease with low tendency to progression. Three stages of development of human prostate tumors have been identified: intraepithelial neoplasia, adenocarcinoma androgen-dependent, and adenocarcinoma androgen-independent or castration-resistant. Advances in molecular technologies have provided a very rapid progress in our understanding of the genomic events responsible for the initial development and progression of prostate cancer. These studies have shown that prostate cancer genome displays a relatively lo

SUBMITTER: Testa U 

PROVIDER: S-EPMC6789661 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature