Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome.

ABSTRACT: Radiation-induced gastrointestinal syndrome (RIGS) is a limiting factor for therapeutic abdominopelvic radiation and is predicted to be a major source of morbidity in the event of a nuclear accident or radiological terrorism. In this study, we developed an in vivo mouse-modeling platform that enables spatial and temporal manipulation of potential RIGS targets in mice following whole-abdomen irradiation without the confounding effects of concomitant hematopoietic syndrome that occur following whole-body irradiation. We then tested the utility of this platform to explore the effects of transient Wnt pathway activation on intestinal regeneration and animal recovery following induction of RIGS. Our results demonstrate that intestinal epithelial suppression of adenomatous polyposis coli (Apc) m

SUBMITTER: Romesser PB 

PROVIDER: S-EPMC6789742 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature