Fenofibrate Nanocrystal Composite Microparticles for Intestine-Specific Oral Drug Delivery System.

ABSTRACT: Hydrophobic drug nanocrystals (NCs) manufactured by particle engineering have been extensively investigated for enhanced oral bioavailability and therapeutic effectiveness. However, there are significant drawbacks, including fast dissolution of the nanocrystals in the gastric environment, leading to physicochemical instability. To solves this issue, we developed an innovative technique that involves the encapsulation of nanocrystals in composite spherical microparticles (NCSMs). Fenofibrate (FNB) NCs (FNB-NCs) manufactured by a wet stirred media milling (WSMM) technique and an ionotropic crosslinking method were used for FNB-NC encapsulation within gastroresistant NCSMs. Various solid-state methods were used for characterizing NCSMs. The pH-sensitive NCSMs showed a site-specific release pa

SUBMITTER: Kevadiya BD 

PROVIDER: S-EPMC6789785 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature