Predictive Power of In Silico Approach to Evaluate Chemicals against M. tuberculosis: A Systematic Review.

ABSTRACT: Mycobacterium tuberculosis (Mtb) is an endemic bacterium worldwide that causes tuberculosis (TB) and involves long-term treatment that is not always effective. In this context, several studies are trying to develop and evaluate new substances active against Mtb. In silico techniques are often used to predict the effects on some known target. We used a systematic approach to find and evaluate manuscripts that applied an in silico technique to find antimycobacterial molecules and tried to prove its predictive potential by testing them in vitro or in vivo. After searching three different databases and applying exclusion criteria, we were able to retrieve 46 documents. We found that they all follow a similar screening procedure, but few studies exploited equal targets, exploring the interactio

SUBMITTER: Timo GO 

PROVIDER: S-EPMC6789803 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature