Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation.

ABSTRACT:

Background

The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (6.p22) in CN-AML patient blasts. Here, we further investigate the molecular, functional, and prognosis significance of this epigenetic alteration named H3K27me3 HIST1 in NPM1-mutated (NPM1mut) CN-AML.

Results

We found that three quarter of the NPM1mut CN-AML patients were H3K27me3 HIST1^high. H3K27me3 HIST1^high group of patients was associated with a favorable outcome independently of known molecular risk factors. In gene expression profiling, the H3K27me3 HIST1^high mark was associated with lower expression of the histone ge

SUBMITTER: Garciaz S 

PROVIDER: S-EPMC6790061 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature