Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study.

ABSTRACT:

Background

Telogen effluvium (TE) is a form of alopecia characterized by diffuse hair shedding. Vitamin D receptor (VDR) plays a role in hair cycle regulation as it is expressed in follicular keratinocytes and dermal papilla cells.

Purpose

To investigate the association between Cdx1 and Taq1 VDR gene polymorphisms and chronic TE.

Methods

Thirty female patients with chronic TE were selected and 30 healthy, age- and sex-matched volunteers were included as a control group. Detection of VDR gene polymorphisms Taq1 and Cdx1 was done by real-time polymerase chain reaction.

Results

Regarding Taq 1, CC genotype was present in 30% of cases versus 3.3% of controls. TC genotype was present in 33.3% of cases and 36.7% of controls. CC genotype was significantly associated w

SUBMITTER: Seleit I 

PROVIDER: S-EPMC6790134 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature