Vaccine adjuvant activity of emulsified oils from species of the Pinaceae family.

ABSTRACT:

Background

Next to aluminum salts, squalene nanoemulsions comprise the most widely employed class of adjuvants in approved vaccines. Despite their importance, the mechanisms of action of squalene nanoemulsions are not completely understood, nor are the structure/function requirements of the oil composition.

Purpose

In this study, we build on previous work that compared the adjuvant properties of nanoemulsions made with different classes of oil structures to squalene nanoemulsion. Here, we introduce nanoemulsions made with polyprenols derived from species of the Pinaceae family as novel vaccine adjuvant compositions. In contrast with long-chain triglycerides that do not efficiently enhance an immune response, both polyprenols and squalene are comprised of multimeric isoprene

SUBMITTER: Fox CB 

PROVIDER: S-EPMC6790179 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature