Role of angiotensin type 2 receptor in improving lipid metabolism and preventing adiposity.

ABSTRACT: Recent studies on mice with null mutation of the angiotensin type 2 receptor (AT₂R) gene have implicated the involvement of AT₂R in regulating adipocyte size and obesity, a major risk factor for metabolic syndrome. However, the outcome from these studies remains inconclusive. Therefore, current study was designed to test whether pharmacological activation of AT₂R regulates adiposity and lipid metabolism. Male mice (5-weeks old) were pre-treated with vehicle or AT₂R agonist (C21, 0.3 mg/kg, i.p., daily, for 4 days) and fed normal diet (ND). Then these animals were subdivided into ND and high-fat diet (HFD) regimen and concomitantly treated with vehicle or C21 through day 14. Vehicle-treated HFD-fed mice demonstrated an increase in epididymal white

SUBMITTER: Nag S 

PROVIDER: S-EPMC6790297 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature