Clinical correlates of mathematical modeling of cortical spreading depression: Single-cases study.

ABSTRACT:

Introduction

Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis that CSD is underlying migraine aura. The highly individual and complex characteristics of the brain cortex suggest that the geometry might impact the propagation of cortical spreading depression.

Methods

In a single-case study, we simulated the CSD propagation for five migraine with aura patients, matching their symptoms during a migraine attack to the CSD wavefront propagation. This CSD wavefront was simulated on a patient-specific triangulated cortical mesh obtained from individual MRI imaging and personalized diffusivity tensors derived locally from di

SUBMITTER: Kroos JM 

PROVIDER: S-EPMC6790336 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature