Mission Possible: Advances in MYC Therapeutic Targeting in Cancer.

ABSTRACT: MYC is a master transcriptional regulator that controls almost all cellular processes. Over the last several decades, researchers have strived to define the context-dependent transcriptional gene programs that are controlled by MYC, as well as the mechanisms that regulate MYC function, in an effort to better understand the contribution of this oncoprotein to cancer progression. There are a wealth of data indicating that deregulation of MYC activity occurs in a large number of cancers and significantly contributes to disease progression, metastatic potential, and therapeutic resistance. Although the therapeutic targeting of MYC in cancer is highly desirable, there remain substantial structural and functional challenges that have impeded direct MYC-targeted drug development and efficacy. Whi

SUBMITTER: Allen-Petersen BL 

PROVIDER: S-EPMC6790341 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature