Zinc Substitution of Cobalt in Vitamin B₁₂ : Zincobyric acid and Zincobalamin as Luminescent Structural B₁₂ -Mimics.

ABSTRACT: Replacing the central cobalt ion of vitamin B₁₂ by other metals has been a long-held aspiration within the B₁₂ -field. Herein, we describe the synthesis from hydrogenobyric acid of zincobyric acid (Znby) and zincobalamin (Znbl), the Zn-analogues of the natural cobalt-corrins cobyric acid and vitamin B₁₂ , respectively. The solution structures of Znby and Znbl were studied by NMR-spectroscopy. Single crystals of Znby were produced, providing the first X-ray crystallographic structure of a zinc corrin. The structures of Znby and of computationally generated Znbl were found to resemble the corresponding Co^II -corrins, making such Zn-corrins potentially useful for investigations of B₁₂ -dependent processes. The singlet excited state of Znb

SUBMITTER: Kieninger C 

PROVIDER: S-EPMC6790578 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature