Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort.

ABSTRACT:

Scope

Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome.

Methods and results

A case-control study nested in the prospective Three-City study includes participants aged ≥65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gender, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap-enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium-chain

SUBMITTER: Low DY 

PROVIDER: S-EPMC6790579 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature