External validation of a prognostic model to predict survival of patients with sentinel node-negative melanoma.

ABSTRACT:

Background

Identifying patients with sentinel node-negative melanoma at high risk of recurrence or death is important. The European Organisation for Research and Treatment of Cancer (EORTC) recently developed a prognostic model including Breslow thickness, ulceration and site of the primary tumour. The aims of the present study were to validate this prognostic model externally and to assess whether it could be improved by adding other prognostic factors.

Methods

Patients with sentinel node-negative cutaneous melanoma were included in this retrospective single-institution study. The β values of the EORTC prognostic model were used to predict recurrence-free survival and melanoma-specific survival. The predictive performance was assessed by discrimination (c-index) and calibra

SUBMITTER: Ipenburg NA 

PROVIDER: S-EPMC6790583 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature