Persistent C-peptide is associated with reduced hypoglycaemia but not HbA_1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?

ABSTRACT:

Aims

Most people with Type 1 diabetes have low levels of persistent endogenous insulin production. The Diabetes Control and Complications Trial showed that close to diagnosis preserved endogenous insulin was associated with lower HbA_1c , hypoglycaemia and complication rates, when intensively treated. We aimed to assess the clinical impact of persistent C-peptide on rate of hypoglycaemia and HbA_1c in those with long duration (> 5 years) Type 1 diabetes.

Methods

We conducted a cross-sectional case-control study of 221 people (median age 24 years) with Type 1 diabetes. We confirmed ongoing endogenous insulin secretion by measuring C-peptide after a mixed-meal tolerance test. We compared self-reported hypoglycaemia (n = 160), HbA_1c , insulin dose

SUBMITTER: Marren SM 

PROVIDER: S-EPMC6790586 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature