Metagenomic analysis reveals a rich bacterial content in high-risk prostate tumors from African men.

ABSTRACT:

Background

Inflammation is a hallmark of prostate cancer (PCa), yet no pathogenic agent has been identified. Men from Africa are at increased risk for both aggressive prostate disease and infection. We hypothesize that pathogenic microbes may be contributing, at least in part, to high-risk PCa presentation within Africa and in turn the observed ethnic disparity.

Methods

Here we reveal through metagenomic analysis of host-derived whole-genome sequencing data, the microbial content within prostate tumor tissue from 22 men. What is unique about this study is that patients were separated by ethnicity, African vs European, and environments, Africa vs Australia.

Results

We identified 23 common bacterial genera between the African, Australian, and Chinese prostate tumor samp

SUBMITTER: Feng Y 

PROVIDER: S-EPMC6790596 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature