Vagus nerve stimulation dampens intestinal inflammation in a murine model of experimental food allergy.

ABSTRACT:

Background

The vagus nerve has emerged as an important modulator of the intestinal immune system. Its anti-inflammatory properties have been previously shown in innate and Th1/Th17 predominant inflammatory models. To what extent the vagus nerve is of importance in Th2 inflammatory responses like food allergy is still unclear. In this study, we therefore aimed to investigate the effect of vagotomy (VGX) and vagus nerve stimulation (VNS), on the development and severity of experimental food allergy.

Methods

Balb/C mice were first sensitized with ovalbumin (OVA) in the presence of alum. Prior to oral challenges with OVA, mice were subjected to VGX or VNS. Disease severity was determined by assessing severity and onset of diarrhoea, OVA-specific antibody production, mast cell nu

SUBMITTER: Bosmans G 

PROVIDER: S-EPMC6790670 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature