The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma.

ABSTRACT:

Background

Mepolizumab and omalizumab are treatments for distinct but overlapping severe asthma phenotypes.

Objective

To assess if patients eligible for both biologics but not optimally controlled with omalizumab experience improved asthma control when switched directly to mepolizumab.

Methods

OSMO was a multicenter, open-label, single-arm, 32-week trial in patients with ≥2 asthma exacerbations in the year prior to enrollment, despite receiving high-dose inhaled corticosteroids and other controller(s), plus omalizumab (≥4 months). At baseline, patients with blood eosinophil counts ≥150 cells/µL (or ≥300 cells/µL in the prior year) and an Asthma Control Questionnaire (ACQ)-5 score ≥1.5 discontinued omalizumab and immediately commenced mepolizumab 100 mg subcutaneously

SUBMITTER: Chapman KR 

PROVIDER: S-EPMC6790683 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature