Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study.

ABSTRACT:

Objective

Metabolic syndrome and obesity are risk factors for chronic kidney disease. However, early kidney alterations may escape diagnosis in these conditions due to glomerular hyperfiltration. Uromodulin, a glycoprotein exclusively synthesized in tubular cells of the thick ascending limb of Henle's loop, is a novel tissue-specific biomarker for kidney function. In contrast to the commonly used markers creatinine and cystatin C, serum uromodulin does not primarily depend on glomerular filtration. We hypothesized that serum uromodulin is a marker for metabolic syndrome and related components.

Design

The analyses included 1088 participants of the population-based KORA F4 study aged 62-81 years. Metabolic syndrome was present in 554 participants. After a mean follow-up time o

SUBMITTER: Then C 

PROVIDER: S-EPMC6790901 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature