A General Acid-Mediated Hydroaminomethylation of Unactivated Alkenes and Alkynes.

ABSTRACT: In comparison to the extensively studied metal-catalyzed hydroamination reaction, hydroaminomethylation has received significantly less attention despite its considerable potential to streamline amine synthesis. State-of-the-art protocols for hydroaminomethylation of alkenes rely largely on transition-metal catalysis, enabling this transformation only under highly designed and controlled conditions. Here we report a broadly applicable, acid-mediated approach to the hydroaminomethylation of unactivated alkenes and alkynes. This methodology employs cheap, readily available, and bench-stable reactants and affords the desired amines with excellent functional group tolerance and impeccable regioselectivity. The broad scope of this transformation, as well as mechanistic investigations and in sit

SUBMITTER: Kaiser D 

PROVIDER: S-EPMC6790944 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature