Puberty is a critical window for the impact of diet on mammary gland development in the rabbit.

ABSTRACT:

Background

Nutritional changes can affect future lactation efficiency. In a rabbit model, an obesogenic diet initiated before puberty and pursued throughout pregnancy enhances mammary differentiation, but when started during the neonatal period can cause abnormal mammary development in early pregnancy. The aim of this study was to investigate the impact of an unbalanced diet administered during the pubertal period only.

Results

Consuming an obesogenic diet at puberty did not affect either metabolic parameters or certain maternal reproductive parameters at the onset of adulthood. In contrast, at Day 8 of pregnancy, epithelial tissue showed a lower proliferation rate in obesogenic-diet fed rabbits than in control-diet fed rabbits. Wap and Cx26 genes, mammary epithelial cell di

SUBMITTER: Hue-Beauvais C 

PROVIDER: S-EPMC6790954 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature