A registration method for improving quantitative assessment in probabilistic diffusion tractography.

ABSTRACT: Diffusion MRI-based probabilistic tractography is a powerful tool for non-invasively investigating normal brain architecture and alterations in structural connectivity associated with disease states. Both voxelwise and region-of-interest methods of analysis are capable of integrating population differences in tract amplitude (streamline count or density), given proper alignment of the tracts of interest. However, quantification of tract differences (between groups, or longitudinally within individuals) has been hampered by two related features of white matter. First, it is unknown to what extent healthy individuals differ in the precise location of white matter tracts, and to what extent experimental factors influence perceived tract location. Second, white matter lacks the gross neuroanat

SUBMITTER: Waugh JL 

PROVIDER: S-EPMC6790978 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature