Does a modifiable risk factor score predict disability worsening in people with multiple sclerosis?

ABSTRACT:

Background

Risk factors for chronic disease include smoking, hazardous alcohol consumption, physical inactivity, unhealthy body mass index and poor diet (SNAP factors). In multiple sclerosis (MS) SNAP factors are associated with health outcomes such as disability in cross-sectional studies, but longitudinal data are lacking.

Objective

The objective of this study was to assess whether a combined SNAP risk score predicts disability worsening.

Methods

Longitudinal self-reported data from two time-points 2.5 years apart from an international survey of 1225 people with MS were used in linear regression models adjusted for potential confounding. Disability worsening was measured using the patient-derived Multiple Sclerosis Severity Score.

Results

The majority (62%) h

SUBMITTER: Marck CH 

PROVIDER: S-EPMC6791040 | biostudies-literature | 2019 Oct-Dec

REPOSITORIES: biostudies-literature