Tecoma stans: Alkaloid Profile and Antimicrobial Activity.

ABSTRACT:

Aim

Tecoma stans (L.) Kunth is a promising species in the trumpet creeper family Bignoniaceae. This study aimed at showing the antibacterial and antifungal potentials of T. stans methanolic leaf extract (TSME) correlated to its phytoconstituents.

Materials and methods

The antimicrobial potential of TSME was evaluated using agar diffusion method. The main alkaloids were separated on silica gel column and identified using nuclear magnetic resonance spectral analysis. Molecular docking was performed for the isolated compounds against MurD ligase, penicillin-binding protein, and dihydropteroate synthase enzyme to rationalize the observed antibacterial effect.

Results and discussion

TSME showed significant antibacterial effect against all tested microorganism

SUBMITTER: Bakr RO 

PROVIDER: S-EPMC6791079 | biostudies-literature | 2019 Oct-Dec

REPOSITORIES: biostudies-literature