The effects of weight loss and metformin on cognition among breast cancer survivors: Evidence from the Reach for Health study.

ABSTRACT:

Objective

Breast cancer survivors experience problems with cognition that interfere with daily life and can last for years. In the general population, obesity and diabetes are risk factors for cognitive decline, and weight loss can improve cognition; however, the impact of intentional weight loss on cancer survivors' cognition has not been tested. We investigated the impact of weight loss and metformin on changes in cognitive function in a sample of breast cancer survivors.

Methods

Overweight/obese postmenopausal breast cancer survivors (n = 333) were randomized to a weight loss intervention versus control and metformin versus placebo in a 2 × 2 factorial design. Outcomes were changes in five cognitive domains from baseline to 6 months measured by objective neurocognitive te

SUBMITTER: Hartman SJ 

PROVIDER: S-EPMC6791123 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature