Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.

ABSTRACT: We have recently found that PE21, an extract from the white willow Salix alba, slows chronological aging and prolongs longevity of the yeast Saccharomyces cerevisiae more efficiently than any of the previously known pharmacological interventions. Here, we investigated mechanisms through which PE21 delays yeast chronological aging and extends yeast longevity. We show that PE21 causes a remodeling of lipid metabolism in chronologically aging yeast, thereby instigating changes in the concentrations of several lipid classes. We demonstrate that such changes in the cellular lipidome initiate three mechanisms of aging delay and longevity extension. The first mechanism through which PE21 slows aging and prolongs longevity consists in its ability to decrease the intracellular concentration of free

SUBMITTER: Medkour Y 

PROVIDER: S-EPMC6791382 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature