Ontology highlight
ABSTRACT:
SUBMITTER: Sprooten J
PROVIDER: S-EPMC6791419 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Oncoimmunology 20190718 11
Dendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pulsed with a source of tumor-associated antigens (TAAs) in the context of standardized maturation-cocktails, followed by their reinfusion. Extensive evidence has confirmed that DC-based vaccines can generate TAA-specific, cytotoxic T cells. Nonetheless, clinical efficacy of DC-based vaccines remains suboptimal, ...[more]