Genetics of idiopathic inflammatory myopathies: insights into disease pathogenesis.

ABSTRACT:

Purpose of review

To review the advances that have been made in our understanding of the genetics of idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on dermatomyositis and polymyositis.

Recent findings

Fine-mapping studies in the major histocompatibility complex region in Caucasian and Korean populations have identified novel human leukocyte antigen (HLA) variants that are associated with autoantibody subgroups in IIM. Differences in HLA associations have been identified between Caucasian adult-onset and juvenile-onset patients with anti-TIF1 autoantibodies, suggesting distinct aetiologies in these patients. For some autoantibodies, the strongest associations identified are specific amino acid positions within HLA molecules, providing me

SUBMITTER: Rothwell S 

PROVIDER: S-EPMC6791565 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature